Transgenerational genetic effects on phenotypic variation and disease risk

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Transgenerational genetic effects on phenotypic variation and disease risk

Traditionally, we understand that individual phenotypes result primarily from inherited genetic variants together with environmental exposures. However, many studies showed that a remarkable variety of factors including environmental agents, parental behaviors, maternal physiology, xenobiotics, nutritional supplements and others lead to epigenetic changes that can be transmitted to subsequent g...

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Fractal and Transgenerational Genetic Effects on Phenotypic Variation and Disease Risk

Traditionally, we understand that individual phenotypes result primarily from inherited genetic variants together with environmental exposures. However, many studies showed that a remarkable variety of factors including environmental agents, parental behaviors, maternal physiology, xenobiotics, nutritional supplements and others lead to epigenetic changes that can be transmitted to subsequent g...

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Genetic and Phenotypic Variation for Flowering Time Genes in Barley (Hordeum vulgare)

Objective: Flowering Time (FT) in cereals controlled by genes that had a main factor on plant development. Methods: Genetic and phenotypic diversity of four flowering time genes (FT2, FT3, FT4, Ppd-H1) in 19 genotypes of cultivated and wild barley was evaluated and a total of 107 alleles were amplified. Genotypes based on days to flowering time and molecular data were grouped into earl...

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Genetic and Phenotypic Variation for Flowering Time Genes in Barley (Hordeum vulgare)

Objective: Flowering Time (FT) in cereals controlled by genes that had a main factor on plant development. Methods: Genetic and phenotypic diversity of four flowering time genes (FT2, FT3, FT4, Ppd-H1) in 19 genotypes of cultivated and wild barley was evaluated and a total of 107 alleles were amplified. Genotypes based on days to flowering time and molecular data were grouped into earl...

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DNA methylation mediates genetic variation for adaptive transgenerational plasticity.

Environmental stresses experienced by individual parents can influence offspring phenotypes in ways that enhance survival under similar conditions. Although such adaptive transgenerational plasticity is well documented, its transmission mechanisms are generally unknown. One possible mechanism is environmentally induced DNA methylation changes. We tested this hypothesis in the annual plant Polyg...

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ژورنال

عنوان ژورنال: Human Molecular Genetics

سال: 2009

ISSN: 0964-6906,1460-2083

DOI: 10.1093/hmg/ddp366